GS-7340 (fuMarate)

Name	GS-7340 Fumarate
Synonyms	vemlidy GS-7340 Fumarate GS-7340 (fuMarate) Tenofovir alafenamide-19 tenofovir alafenamide fumarate (TAF)
CAS	379270-38-9
EINECS	223-388-5

Molecular Formula	C25H33N6O9P
Molar Mass	592.55
Solubility	DMSO: ≥ 36 mg/mL
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
In vitro study	Tenofovir alafenamide fumarate (GS-7340 fumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT.
In vivo study	Tenofovir alafenamide fumarate (GS-7340 fumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF).

Last Update：2024-01-02 23:10:35

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Product Name: GS-7340 (fumarate) Visit Supplier Webpage Request for quotation
CAS: 379270-38-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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GS-7340 (fuMarate)

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